人结肠癌细胞 GP2d

GP2d 细胞系是人结肠癌细胞，源自一位患者的结肠。细胞形态为上皮细胞样，生长特性为贴壁生长。培养基为 DMEM 含 10% FBS，生长条件为 37℃， 5% CO2。该细胞系适合研究结肠癌的生物学特性和治疗方法。

人结肠癌细胞（人）组织来源为结肠， Cellosaurus 登记疾病： Colon adenocarcinoma。常用于结直肠癌研究：增殖/凋亡、侵袭转移、化疗与免疫治疗（含 OVA 等抗原模型）。常见用途：细胞增殖/凋亡与信号通路研究、外源基因表达与功能验证、体外药物敏感性/毒性测试；部分背景可用于异种移植（成瘤/转移）模型（以实际种属与免疫缺陷背景为准）。用途说明依据 Cellosaurus 登记信息与公开文献归纳，仅供参考。

1. Two newly established cell lines derived from the same colonic adenocarcinoma exhibit differences in EGF-receptor ligand and adhesion molecule expression.
   Int J Cancer · 1995 · PMID 7601566 · 被引 15 · 奠基/最早文献
2. Signatures of mutation and selection in the cancer genome.
   Nature · 2010 · PMID 20164919 · 被引 573
3. APC mutations in sporadic colorectal tumors: A mutational "hotspot" and interdependence of the "two hits".
   Proc Natl Acad Sci U S A · 2000 · PMID 10737795 · 被引 401
4. Analysis of P53 mutations and their expression in 56 colorectal cancer cell lines.
   Proc Natl Acad Sci U S A · 2006 · PMID 16418264 · 被引 209
5. Mutated epithelial cadherin is associated with increased tumorigenicity and loss of adhesion and of responsiveness to the motogenic trefoil factor 2 in colon carcinoma cells.
   Proc Natl Acad Sci U S A · 1999 · PMID 10051639 · 被引 86

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